Beck JD, Offenbacher S
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چکیده
Materials and Methods: 1391 individuals (age 45-64 years old) randomly selected from Dental Atherosclerosis Risk in Communities Study (Dental ARIC). Clinical measures collected included PD, CAL on six sites for all teeth. Case definition of periodontal disease consists of following three degrees; 1) severe periodontitis: >2 interproximal sites ( not on same tooth) with > 6mm CAL and 1 or more interproximal sites with PD >5mm: 2) initial periodontitis: > 2 interproximal sites with 4 or 5mm CAL (not on same tooth); and 3) healthy/gingivitis: the other individuals. Periodontal organisms selected were representatives from Socransky's clusters; P.gingivalis, T. forsythensis, and T. denticola from “red” and P. intermedia, P nigrescens, F. nucleatum, Peptostreptococcus micros, and Campylobacter rectus from “orange”, and A.a. Plaque organisms were measured using DNA checkerboards. The samples were assayed for IgG antibody levels. Distributions of the organisms and antibodies were divided into quartile and then dichotomized as high vs. low. Participants were defined as never smokers, former smokers, or current smokers, and subclassified light (< 20 pack-years) or heavy smokers (>20 pack-years). Age was dichotomized as <65 years or not. Race was either African American or Caucasian. Also diabetes, hypertension and obesity were reported. All collected data were analyzed with “principal component analysis”
منابع مشابه
Bacterial Characterization in Health and Periodontal Diseases During Induced Gingival Inflammation
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